Materials for Biomedical Applications



Lecture 1: Course Introduction (Download PDF)

–          Biomaterials Defined

–          Structural Hierarchy in Materials and Biology


Lecture 2: Biomaterials Surfaces: Physics (Download PDF)

–          Surface (vs. Bulk) Structure and Properties

–          Surface Energy

–          Adsorption, Segregation, and Reconstruction at Surfaces


Lecture 3: Biomaterials Surfaces: Chemistry (Download PDF)

–           Reactions at Surfaces: Chemisorption, Corrosion


Lecture 4: Biomaterials Surfaces: Chemistry (cont.) (Download PDF)

–           Hydrolysis (Dr. Taniguchi) (Download PDF)


Lecture 5: Protein-Surface Interactions (Download PDF)

–          Proteins: Structure, Properties, Functions

–          Protein Adsorption: Langmuir Model


Lecture 6: Protein-Surface Interactions (cont.) (Download PDF)

–          Protein Adbsorption: Complex Phenomena, Measurement


Lecture 7: Cell-Surface Interactions: Host Response to Biomaterials (Download PDF)

–          Cell Adhesion Mechanisms

–          Coagulation Cascade


Lecture 8: Cell-Surface Interactions: Host Response to Biomaterials (cont.) (Download PDF)

–          Immune Response: Alternative Complement Activation


Lecture 9: Surface Modification Methods (Download PDF)

–          Purposes

–          Plasma Treatments

–          Organic Coatings (Dr. Taniguchi) (Download PDF)


Lecture 10: Surface Modification Methods (cont.) (Download PDF)

–          Polymer Coatings

–          Patterned Surfaces


Lecture 11: Surface Characterization (Download PDF)

–          In Vacuum: XPS/ESCA, AES, SIMS


Lecture 12: Surface Characterization In situ (Download PDF)

–          Contact Angle, AFM


Lecture 13: Quantifying Cell Behavior (Download PDF)

–          Cell Cultures

–          Cellular Assays: Adhesion, Migration, Proliferation


Lecture 14: Quantifying Cell Behavior (cont.) (Download PDF)

–          Cellular Assays: Differentiation, Function


Lecture 15: Statistical Analysis (Download PDF)

–          Error Sources, Distribution Functions, t- test


Lecture 16: Statistical Analysis (cont.) (Download PDF)

–          Fisher Test, Regression Methods


Lecture 17: Biosensors and Diagnostic Devices (Download PDF)

–          Biological Elements

–          Transduction Mechanisms

–          Properties

–          Examples: Fiber Optic Biosensors, Nanobarcodes


Lecture 18: Drug Delivery: Controlled Release (Dr. Taniguchi) (Download PDF)

–          Chemically-controlled Devices


Lecture 19: Drug Delivery: Controlled Release (cont.) (Download PDF)

–          Diffusion-controlled, Membrane-based and Osmotic Devices


Lecture 20: Drug Delivery: Controlled Release (cont.) (Download PDF)

–          Methods: Transdermal, Colloidal Vehicles

–          Mechanical Pumps


Lecture 21: Biomaterials for Organ Replacement (Download PDF)

–          Organ Replacement Therapies

–          Mechanical Properties

–          Bone Substitutes


Lecture 22: Tissue Engineering (Download PDF)

–          Cell Types

–          Approaches: In vitro, In vivo, Ex vivo/Cell Encapsulation

–          Scaffolds: Design and Fabrication


Lecture 23: Tissue Engineering (cont.) (Download PDF)

–          Case Examples: Artificial Pancreas, Cartilage, Nerve Regeneration


Lecture 24: FDA Regulatory Issues and Course Evaluations (Download PDF)



Mayes, Anne. 3.051J Materials for Biomedical Applications, Spring 2006. (Massachusetts Institute of Technology: MIT OpenCourseWare), (Accessed 23 Aug, 2012). License: Creative Commons BY-NC-SA

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